Avichai Shimoni

Prof. Avichai Shimoni is the Director of Bone Marrow Transplantation at Sheba Medical Center. He is a hemato-oncologist specializing in cellular therapies and blood cancer care. Forbes lists him among Israel’s Best Doctors for 2025 and 2026.

Advanced Blood Cancer Treatments

Prof. Shimoni leads a high-volume program for complex and high-risk hematologic malignancies. He performs both allogeneic and autologous stem cell transplants. The specialist also provides CAR T-cell therapy for patients with leukemia, lymphoma, and multiple myeloma. This immunotherapy uses the body's own cells to fight cancer.

He delivers curative therapies by combining transplantation with modern techniques. This approach helps patients overcome aggressive cancers. Every plan is personalized based on disease biology and the patient's condition.

Clinical Expertise

The doctor treats a wide range of blood disorders and cancers:

• Acute leukemias including AML and ALL
• Chronic Lymphocytic Leukemia (CLL)
• Non-Hodgkin (NHL) and Hodgkin lymphoma
• Multiple myeloma and myelofibrosis
• Myelodysplastic syndromes (MDS)
• Aplastic, Sickle Cell, and Fanconi anemia
• Chronic Myeloid Leukemia (CML)

Professional Experience

• Director, Bone Marrow Transplantation Department, Sheba Medical Center
• Chairman, Department of Hematology, Tel Aviv University
• Professor of Hematology at Tel Aviv University

Education and Training

Prof. Shimoni obtained his medical degree and specialized in hemato-oncology. He completed a bone marrow transplantation fellowship at MD Anderson Cancer Center. This institution in the USA conducts oncology research. His clinical training focused on high-risk disease management and relapsed cases.

Research and Academic Work

The specialist has authored over 250 scientific papers in peer-reviewed journals. His research focuses on stem cell transplantation and CAR T-cell applications. He plays a key role in training future hematologists in Israel. These academic efforts bridge the gap between clinical research and daily practice.

Specialized Procedures

• Haploidentical stem cell transplantation
• Allogenic bone marrow transplantation from related and unrelated donors
• Therapeutic apheresis and selective apheresis — a process that filters specific components from the blood
• Plasmapheresis and plasma exchange — a procedure that removes and replaces the liquid portion of the blood
• Bone marrow biopsy and immunohistochemistry — a lab test used to identify specific cancer cells in tissue