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Dr. Motti works at the Neurosurgery Department at Maria Cecilia Hospital, as the coordinator of the Gamma Knife Operating Unit, and neurosurgeon in charge of the Stereotaxic Neurosurgery Unit, one of the few centers in Italy, which specializes in the Gamma Knife treatments.  

He is an active member of several research companies focused on Gamma Knife: Italian Society of Neurosurgery, Rome; Gamma Knife Society, Stockholm; European Gamma Knife Society, Madrid. In 1982 he obtained the patent for interfacing the Talairach stereotaxic helmet with computerized axial tomography methods. In 1987 he made the first brain implantation of dopaminergic cells in Parkinson's disease in Italy. He is responsible for training courses at national and international levels, such as courses in Stereotaxic Techniques, Functional Neurosurgery, Radiosurgery at the School of Specialization in Neurosurgery, by the University of Milan; He was an Invited speaker at the "Compliance in radiosurgery" course at the GKSociety meeting in Seoul, South Korea; Organizer of the First European Meeting of Gamma Knife Users, in 1996 in Milan and its subsequent editions.

He is often invited as an instructor in the first weeks of the opening of the new Gamma Knife centers, such as from the Hospital of the University of California Davis, Sacramento, California; or the Arsenji Hospital in Bucharest, Romania etc.

Author and co-author of about 100 publications and contributors to national and international journals. In the seventies he contributed as Assistant Editor to the editorial board of the Journal of Neurosurgical Sciences. For twenty years he was a Consultant in medical libraries as an expert in research techniques and bibliographic archives.